- oral idarubicin advanced breast cancer


oral idarubicin advanced breast cancer

the role of IDA in the treatment of advanced breast cancer. Key words: Breast cancer, advanced, Idarubicin, oral adminis- tration. Idarubicin (IDA), a more lipophilic derivative of daun- orubicin, has shown activity after oral administration. Pharmacokinetic studies (1, 2) have revealed that the oral bioavailability varies between 30-40 %.

Idarubicin, a new analogue of daunorubicin, was administered to 27 patients with advanced breast cancer in a phase II trial. The drug was given orally at a dose of 30-35 mg/m2 every 3 weeks.

Jun 01, 2000 · Oral idarubicin (IDA) is an active drug in metastatic breast cancer, but its role in the management of this tumor is yet not established completely. To investigate a new modality of IDA administration, a dose-finding study was designed with hyperfractionated doses. The purpose was to determine the maximum tolerated dose (MTD), the dose-limiting toxicity (DLT), and the Cited by: 22.

breast cancer that has spread to other parts of the body (advanced breast cancer) How idarubicin works. It works by stopping cancer cells separating into two new cells, so it blocks the growth of the cancer. How you have idarubicin. You have idarubicin as capsules or you might have it .